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Article

Circulating myeloid dendritic cell directly isolated from patients with chronic myelogenous leukemia are functional and carry the bcr-abl translocation.

Leukemia research - 1 Jul 2006

Orsini Enrica, Calabrese Elisabetta, Maggio Roberta, Pasquale Alessia, Nanni Mauro, Trasarti Stefania, Tafuri Agostino, Guarini Anna, Foa Robert

Abstract excerpt

Leukemic bcr-abl positive dendritic cells (DCs) are likely to be present in vivo in chronic myelogenous leukemia (CML) patients, but no data are available on their functional qualities. We analyzed the circulating BDCA-1+ myeloid DC compartment in 15 chronic phase CML patients. Phenotypic features of CML DCs were comparable with that of normal DCs, except for the CD80 and CD40 antigens, significantly...

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Share to Antigens, CD1
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Dendritic Cells

Share to Fusion Proteins, bcr-abl

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Lipopolysaccharides

Share to Translocation, Genetic

Source

Identifiers

PMID: 16527350
DOI: 10.1016/j.leukres.2005.11.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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