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Article

Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2004

Cignetti Alessandro, Vallario Antonella, Roato Ilaria, Circosta Paola, Allione Bernardino, Casorzo Laura, Ghia Paolo, Caligaris-Cappio Federico

Abstract excerpt

Primary acute myeloid leukemia cells can be induced to differentiate into dendritic cells (DC). In the presence of GM-CSF, TNF-alpha, and/or IL-4, leukemia-derived DC are obtained that display features of immature DC (i-DC). The aim of this study was to determine whether i-DC of leukemic origin could be further differentiated into mature DC (m-DC) and to evaluate the possibility that leukemic m-DC could be...

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Source

Identifiers

PMID: 15295005
DOI: 10.4049/jimmunol.173.4.2855

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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