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Article

MMP14 gene polymorphisms in chronic obstructive pulmonary disease.

International journal of molecular medicine - 1 Apr 2006

Saitoh Wataru, Sakamoto Tohru, Hegab Ahmed E, Nomura Akihiro, Ishii Yukio, Morishima Yuko, Kai Sachiko, Iizuka Takashi, Kiwamoto Takumi, Matsuno Yosuke, Massoud Hosam H, Massoud Hosny M, Hassanein Khalid M, Sekizawa Kiyohisa

Abstract excerpt

Proteinase/antiproteinase imbalance is a widely accepted theory for the pathogenesis of COPD. Among various proteinases, matrix metalloproteinases (MMPs) digest extracellular matrix of the lung and play significant roles in the development of COPD. Polymorphisms of an MMP that upregulate its activity may result in the degradation of the lung matrix. A case-control study was performed to investigate the...

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PMID: 16525718

Genes

MMP14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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