Article
Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians.
Respiratory medicine - 1 Jan 2005
Hegab A E, Sakamoto T, Uchida Y, Nomura A, Ishii Y, Morishima Y, Mochizuki M, Kimura T, Saitoh W, Kiwamoto T, Iizuka T, Massoud H H, Massoud H M, Hassanein K M, Sekizawa K
Abstract excerpt
Proteinase/antiproteinase imbalance is recognized to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). A relative increase in the activities of matrix metalloproteinases might be caused by mutations of tissue inhibitor of metalloproteinase2 (TIMP2). Recently, two polymorphisms of the TIMP2 gene, +853 G/A and -418 G/C (+551 and -720 from the translation initiation site),...
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