Article
Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.
Protein science : a publication of the Protein Society - 1 Oct 2018
Mesrouze Yannick, Bokhovchuk Fedir, Izaac Aude, Meyerhofer Marco, Zimmermann Catherine, Fontana Patrizia, Schmelzle Tobias, Erdmann Dirk, Furet Pascal, Kallen Joerg, Chène Patrick
Abstract excerpt
Many interactions between proteins are mediated by intrinsically disordered regions (IDRs). Intrinsically disordered proteins (IDPs) do not adopt a stable three-dimensional structure in their unbound form, but they become more structured upon binding to their partners. In this communication, we study how a bound IDR adapts to mutations, preventing the formation of hydrogen bonds at the binding interface that...
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