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Cancer Stem Cells: At the Headwaters of Tumor Development

20 Sept 2006

Abstract excerpt

According to the cancer stem cell hypothesis, only a subpopulation of cells within a cancer has the capacity to sustain tumor growth. This subpopulation of cells is made up of cancer stem cells, which are defined simply as the population of cells within a tumor that can self-renew, differentiate, and regenerate a phenocopy of the cancer when injected in vivo. Cancer stem cells have now been prospectively isolated...

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PMID: 18039097
DOI: 10.1146/annurev.pathol.2.010506.091847

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