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Article

Impaired RNA splicing of 5'-regulatory sequences of the astroglial glutamate transporter EAAT2 in human astrocytoma.

Journal of neurology, neurosurgery, and psychiatry - 1 Nov 2001

Münch C, Penndorf A, Schwalenstöcker B, Troost D, Ludolph A C, Ince P, Meyer T

Abstract excerpt

A loss of the glutamate transporter EAAT2 has been reported in the neoplastic transformation of astrocytic cells and astrocytoma. The RNA expression of EAAT2 and five 5'-regulatory splice variants was investigated to identify alterations of the post-transcriptional EAAT2 gene regulation in human astrocytic tumours. Three known (EAAT2, HBGTII, and HBGTIIC) and two novel (EAAT2/3 and EAAT2/31) EAAT2 transcripts...

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Identifiers

PMID: 11606683
DOI: 10.1136/jnnp.71.5.675
PMCID: PMC1737593

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Source receipt: pubmed, retrieved 7 Sept 2026.

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