Missense mutations in the BRCT domain of BRCA-1 from high-risk women frequently perturb strongly hydrophobic amino acids conserved among mammals.

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Article

Missense mutations in the BRCT domain of BRCA-1 from high-risk women frequently perturb strongly hydrophobic amino acids conserved among mammals.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2004

Figge Meaghan A, Blankenship Lynda

Abstract excerpt

Inherited missense mutations in the tumor suppressor gene, BRCA-1, may predispose to breast or ovarian cancer, but the exact effects on the protein are generally unknown. The COOH-terminal region of BRCA-1 encodes two BRCT repeats, which are partially conserved in mammalian species (human, dog, rat, and mouse; 60% amino acid identity). A bioinformatic analysis was conducted to evaluate 246 BRCT missense mutations...

Topics

Amino Acid Sequence
Amino Acids
Animals
Breast Neoplasms
Databases, Factual
Dogs
Female
Genes, BRCA1
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrophobic and Hydrophilic Interactions

Mice

Mutation, Missense

National Institutes of Health (U.S.)

Ovarian Neoplasms

Rats

United States

Source

Open in PubMed

Identifiers

PMID: 15184261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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