Article
Spectrum of mutations in BRCA1 gene in hereditary forms of breast and ovarian cancer in Russian families.
Bulletin of experimental biology and medicine - 1 Sept 2003
Loginova A N, Pospekhova N I, Lyubchenko L N, Budilov A V, Zakhar'ev V M, Gar'kavtseva R F, Ginter E K, Karpukhin A V
Abstract excerpt
The 5382insC mutation predominated (94%) in the spectrum of detected mutations of BRCA1 gene. High incidence of this mutation in familial breast cancer detected for the first time attested to origination of 5382insC mutation from the European part of Russia. The percentage of families with mutations in BRCA1 gene and familial predisposition to ovarian cancer was significantly higher than in hereditary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.