Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional characterization of a mutant of Pseudocerastes persicus natriuretic peptide.

Protein and peptide letters - 1 Jan 2006

Elmi Maryam M, Amininasab Mehriar, Hondo Takayuki, Kikuchi Jun, Kuroda Yutaka, Naderi-Manesh Hossein, Sarbolouki Mohammad N

Abstract excerpt

We hereby report on a mutational analysis of a novel natriuretic peptide (PNP), recently isolated by us from the Iranian snake venom. The PNP variant (mutPNP) with four substitutions (G16T, K18S, R21S, G23R) and a disulfide bonded ring shortened by 3 residues. mutPNP peptide was expressed in pET32 and purified by affinity separation on nickel resin followed by RP-HPLC chromatography. The conformation of mutPNP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disulfides

Share to Molecular Weight

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Conformation

Share to Rats, Wistar

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 16515458
DOI: 10.2174/092986606775338452

Genes

PNP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional characterization of a mutant of Pseudocerastes persicus natriuretic peptide.PMID 16515458Read ↗

In-silico screening of missense nsSNPs in Delta-opioid receptor protein and their restoring tendency on MCRT interaction; focusing on dynamic nature.Semantic proximity Read ↗

Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes.Semantic proximity Read ↗

Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution.Semantic proximity Read ↗

NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability.Semantic proximity Read ↗

The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.Semantic proximity Read ↗

KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist.Semantic proximity Read ↗

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance.Semantic proximity Read ↗

[Solid-phase synthesis and biological characterization of S12A-HNTX-IV and R29A-HNTX-IV: two mutants of hainantoxin-IV].Semantic proximity Read ↗

Structural determinants of RXPA380, a potent and highly selective inhibitor of the angiotensin-converting enzyme C-domain.Semantic proximity Read ↗

Effects of naturally occurring charged mutations on the structure, stability, and binding of the Pin1 WW domain.Semantic proximity Read ↗

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.Semantic proximity Read ↗

A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.