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Peptidyl‐prolyl cis‐trans isomerase NIMA‐interacting 1 directly binds and stabilizes Nrf2 in breast cancer

17 Dec 2021

Abstract excerpt

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) has been frequently overexpressed in many types of malignancy, suggesting its oncogenic function. It recognizes phosphorylated serine or threonine (pSer/Thr) of a target protein and isomerizes the adjacent proline (Pro) residue, thereby altering folding, subcellular localization, stability, and function of target proteins. The oncogenic transcription...

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PMID: 34918396
DOI: 10.1096/fj.202100776rr

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