Article
Virological response to darunavir in patients infected with HIV is linked to darunavir resistance-associated mutations corrected by the count of mutations with positive impact and is not associated with pharmacological and combined virological/pharmacological parameters.
Fundamental & clinical pharmacology - 1 Aug 2012
Dailly Eric, Rodallec Audrey, Allavena Clotilde, Deslandes Guillaume, Garnier Elisabeth, Billaud Eric, Ferré Virginie, Reliquet Véronique, Bouquié Régis, Raffi François, Jolliet Pascale
Abstract excerpt
The relationships between virological (darunavir resistance-associated mutations), pharmacological (darunavir trough plasma concentration), combined virological/pharmacological [darunavir genotypic inhibitory quotient (GIQ)] parameters and virological response were evaluated in experienced patients infected with human immunodeficiency virus. In this retrospective study (48 patients), the relationship between...
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