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Article

Role of HIV-1 minority populations on resistance mutational pattern evolution and susceptibility to protease inhibitors.

AIDS (London, England) - 9 Jan 2006

Roquebert Bénédicte, Malet Isabelle, Wirden Marc, Tubiana Roland, Valantin Marc-Antoine, Simon Anne, Katlama Christine, Peytavin Gilles, Calvez Vincent, Marcelin Anne-Geneviève

Abstract excerpt

We investigated, in the protease and GAG cleavage sites, the role of minority populations on the evolution of resistance to a subsequent boosted protease inhibitor (PI) regimen after a first failure to nelfinavir. Two pathways were observed: the addition of mutations to a currently dominant genotype when minority variants are not shown, or the emergence of a minority variant as a dominant strain. These minor...

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Identifiers

PMID: 16511425
DOI: 10.1097/01.aids.0000202650.03279.69

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