Article
TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 2006
Kim Sangsung, Kang Changjoong, Shin Chan Young, Hwang Sun Wook, Yang Young Duk, Shim Won Sik, Park Min-Young, Kim Eunhee, Kim Misook, Kim Byung-Moon, Cho Hawon, Shin Youngki, Oh Uhtaek
Abstract excerpt
TRPV1, a cloned capsaicin receptor, is a molecular sensor for detecting adverse stimuli and a key element for inflammatory nociception and represents biophysical properties of native channel. However, there seems to be a marked difference between TRPV1 and native capsaicin receptors in the pharmacological response profiles to vanilloids or acid. One plausible explanation for this overt discrepancy is the presence...
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