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Article

XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking.

Cancer research - 1 Mar 2006

Pachkowski Brian F, Winkel Scott, Kubota Yoshiko, Swenberg James A, Millikan Robert C, Nakamura Jun

Abstract excerpt

Tobacco smoke produces oxidative and alkylative DNA damage that necessitates repair by base excision repair coordinated by X-ray cross-complementing gene 1 (XRCC1). We investigated whether polymorphisms in XRCC1 alter DNA repair capacity and modify breast cancer risk associated with smoking. To show the functionality of the 280His variant, we evaluated single-strand break (SSB) repair capacity of isogenic Chinese...

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Source

Identifiers

PMID: 16510609
DOI: 10.1158/0008-5472.CAN-05-3388

Genes

XRCC1
SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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