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Article

A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.

Cancer research - 15 Aug 2002

Duell Eric J, Holly Elizabeth A, Bracci Paige M, Wiencke John K, Kelsey Karl T

Abstract excerpt

XRCC1 (X-ray repair cross-complementing group 1) is a base excision repair protein that plays a central role in the repair of DNA strand breaks and base damage from a variety of endogenous and exogenous oxidants including tobacco smoke. One genetic polymorphism (G-->A, Arg-->Gln at codon 399) occurs within a poly(ADP-ribose) polymerase binding region and within the central breast cancer susceptibility gene 1...

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Source

Identifiers

PMID: 12183419

Genes

XRCC1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.PMID 12183419Read ↗

Association between Polymorphisms of X-Ray Repair Cross Complementing Group 1 Gene and Pancreatic Cancer Risk: a Systematic Review with Meta-Analysis.Semantic proximity Read ↗

XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.Semantic proximity Read ↗

Association between X-ray repair cross-complementation group 1 rs25487 polymorphism and pancreatic cancer risk.Semantic proximity Read ↗

A prospective study of XRCC1 (X-ray cross-complementing group 1) polymorphisms and breast cancer risk.Semantic proximity Read ↗

A population-based case-control study of the Arg399Gln polymorphism in DNA repair gene XRCC1 and risk of breast cancer.Semantic proximity Read ↗

X-ray repair cross-complementing group 1 polymorphisms and cancer risks in Asian populations: a mini review.Semantic proximity Read ↗

Selected polymorphisms of DNA repair genes and risk of pancreatic cancer.Semantic proximity Read ↗

Association and Intragenic Single-Nucleotide Polymorphism Interactions of the XRCC1 Polymorphisms for Pancreatic Cancer Susceptibility.Semantic proximity Read ↗

Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk.Semantic proximity Read ↗

XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls.Semantic proximity Read ↗

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