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Article

A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking.

Pharmacogenetics and genomics - 1 Jul 2005

Hu Zhibin, Ma Hongxia, Lu Daru, Zhou Jiannong, Chen Yijiang, Xu Lin, Zhu Jingfu, Huo Xiang, Qian Ji, Wei Qingyi, Shen Hongbing

Abstract excerpt

X-ray repair cross complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base-excision repair pathway. Functional Polymorphisms in the XRCC1 gene may lead to decreased DNA repair capacity and thus confer inherited predisposition to cancer risk. In this case-control study of 710 patients with incident lung cancer and 710 cancer-free controls who were frequency matched on age, sex...

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Source

Identifiers

PMID: 15970793
DOI: 10.1097/01.fpc.0000167329.85163.0d

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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