Article
Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis.
The American journal of pathology - 1 Mar 2006
Korenaga Tatsumi, Yan Jingmin, Sawashita Jinko, Matsushita Takatoshi, Naiki Hironobu, Hosokawa Masanori, Mori Masayuki, Higuchi Keiichi, Fu Xiaoying
Abstract excerpt
Pre-existing amyloid fibrils can induce further polymerization of endogenous precursor proteins in vivo. Thus, transmission of amyloid fibrils (AApoAII) may induce a conformational change in endogenous apolipoprotein A-II and accelerate amyloid deposition in mouse senile amyloidosis. To characterize transmissibility, we examined amyloidosis in the offspring of AApoAII-injected mother mice that possessed the...
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