Article
Amyloidosis modifier genes in the less amyloidogenic a/j mouse strain.
Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2003
Guo Zhanjun, Mori Masayuki, Fu Xiaoying, Yao Junjie, Xing Yanming, Korenaga Tatsumi, Li Guixin, Matsushita Takatoshi, Hosokawa Masanori, Higuchi Keiichi
Abstract excerpt
Apolipoprotein A-II is deposited as an amyloid fibril in aged mice (senile AApoAII amyloidosis). Although mouse strains with the apolipoprotein A-II c allele (Apoa2(c)) generally develop early-onset and severe senile amyloidosis, the A/J strain shows significantly less amyloid deposition. To identify genes that modify spontaneous amyloidosis development in the A/J mouse, we performed a genome-wide screening using...
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