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Article

Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis.

Communications biology - 12 Mar 2021

Illouz Tomer, Nicola Raneen, Ben-Shushan Linoy, Madar Ravit, Biragyn Arya, Okun Eitan

Abstract excerpt

Maternal antibodies (MAbs) protect against infections in immunologically-immature neonates. Maternally transferred immunity may also be harnessed to target diseases associated with endogenous protein misfolding and aggregation, such as Alzheimer's disease (AD) and AD-pathology in Down syndrome (DS). While familial early-onset AD (fEOAD) is associated with autosomal dominant mutations in the APP, PSEN1,2 genes,...

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Share to Immunization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phagocytosis

Share to Plaque, Amyloid

Share to Receptors, IgG

Share to Syk Kinase

Share to Vaccines, DNA

Source

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Identifiers

PMID: 33712740
DOI: 10.1038/s42003-021-01851-6
PMCID: PMC7955073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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