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Article

Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils.

Journal of molecular biology - 15 Feb 2024

Andreotti Giada, Baur Julian, Ugrina Marijana, Pfeiffer Peter Benedikt, Hartmann Max, Wiese Sebastian, Miyahara Hiroki, Higuchi Keiichi, Schwierz Nadine, Schmidt Matthias, Fändrich Marcus

Abstract excerpt

Amyloid resistance is the inability or the reduced susceptibility of an organism to develop amyloidosis. In this study we have analysed the molecular basis of the resistance to systemic AApoAII amyloidosis, which arises from the formation of amyloid fibrils from apolipoprotein A-II (ApoA-II). The disease affects humans and animals, including SAMR1C mice that express the C allele of ApoA-II protein, whereas other...

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PMID: 38199491
DOI: 10.1016/j.jmb.2024.168441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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