Article
Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes.
Genome biology - 1 Jan 2006
Narayanaswamy Rammohan, Niu Wei, Scouras Alexander D, Hart G Traver, Davies Jonathan, Ellington Andrew D, Iyer Vishwanath R, Marcotte Edward M
Abstract excerpt
We have developed spotted cell microarrays for measuring cellular phenotypes on a large scale. Collections of cells are printed, stained for subcellular features, then imaged via automated, high-throughput microscopy, allowing systematic phenotypic characterization. We used this technology to identify genes involved in the response of yeast to mating pheromone. Besides morphology assays, cell microarrays should...
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