Article
A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level.
International journal of cancer - 1 Jul 2014
Wu Xiaopan, Xin Zhenhui, Zhang Wei, Zheng Sujun, Wu Jia, Chen Kangmei, Wang Huifen, Zhu Xilin, Li Zhuo, Duan Zhongping, Li Hui, Liu Ying
Abstract excerpt
Accumulated evidences indicate that single nucleotide polymorphisms (SNP) are associated with risk of hepatocellular carcinoma (HCC). Activating transcription factor 6 (ATF6) is an important modulator of the unfolded protein response (UPR), which is regarded to be involved in carcinogenesis. So we speculate that SNPs in ATF6 may be associated with susceptibility to HCC. We carried out a two-stage association...
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