Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1991

Bradl M, Larue L, Mintz B

Abstract excerpt

Transgenic mice of an inbred black strain were previously produced with the Tyr-SV40E transgene, comprising simian virus 40 transforming sequences driven by the tyrosinase promoter, in order to obtain melanomas; the animals were found to be lighter than normal in coat color, to various degrees. As described here, hypopigmentation resulted from diminished differentiation of melanized pigment granules in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Polyomavirus Transforming
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Simian virus 40

Source

Open in PubMed Open full text

Identifiers

PMID: 1650469
DOI: 10.1073/pnas.88.15.6447
PMCID: PMC52102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.PMID 1650469Read ↗

Transgenic mouse model of malignant skin melanoma.Semantic proximity Read ↗

Transgenic mice. Fade to grey.Semantic proximity Read ↗

Expression of tyrosinase gene in transgenic albino mice: the heritable patterned coat colors.Semantic proximity Read ↗

Histopathogenesis of malignant skin melanoma induced in genetically susceptible transgenic mice.Semantic proximity Read ↗

Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.Semantic proximity Read ↗

A stop-EGFP transgenic mouse to detect clonal cell lineages generated by mutation.Semantic proximity Read ↗

Hair pigmentation in transgenic mice.Semantic proximity Read ↗

Expression of tyrosinase gene in transgenic mice: programmed versus non-programmed expression.Semantic proximity Read ↗

The Tyr (albino) locus of the laboratory mouse.Semantic proximity Read ↗

Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase.Semantic proximity Read ↗

Genetics of dark skin in mice.Semantic proximity Read ↗

Mosaicism of tyrosinase-locus transcription and chromatin structure in dark vs. light melanocyte clones of homozygous chinchilla-mottled mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.