Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.

doi:10.1073/pnas.88.15.6447

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Article

Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1991

Bradl M, Larue L, Mintz B

Abstract excerpt

Transgenic mice of an inbred black strain were previously produced with the Tyr-SV40E transgene, comprising simian virus 40 transforming sequences driven by the tyrosinase promoter, in order to obtain melanomas; the animals were found to be lighter than normal in coat color, to various degrees. A...

Topics

Animals
Antigens, Polyomavirus Transforming
Blotting, Southern
DNA
Female
Genetic Variation
Hair
Hair Color
Male
Melanocytes
Mice
Mice, Inbred C57BL
Mice, Transgenic
Simian virus 40

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