Article
Transgenic mouse model of malignant skin melanoma.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1993
Mintz B, Silvers W K
Abstract excerpt
Tyr-SV40E transgenic mice are specifically susceptible to melanoma due to expression of the oncogene in pigment cells. Mice of the more susceptible lines die young of early-onset eye melanomas, when skin melanomas are still infrequent and benign. To surmount this obstacle, skin from donors of two high-susceptibility lines was grafted to Tyr-SV40E hosts of a low-susceptibility line of the same inbred strain,...
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