Mosaicism of tyrosinase-locus transcription and chromatin structure in dark vs. light melanocyte clones of homozygous chinchilla-mottled mice.

Abstract excerpt

The chinchilla-mottled (cm) mutation at the mouse tyrosinase-encoding locus leads to a transversely striped pattern of dark- and light-grey coat colors in homozygotes. The same basic pattern occurs in various other genotypes and has previously been found to represent the clonal developmental history of melanocytes. In a homozygote such as cm/cm, cis-acting mechanisms would be expected to account for the color...

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