Article
Bioinformatical assay of human gene morbidity.
Nucleic acids research - 1 Jan 2004
Kondrashov Fyodor A, Ogurtsov Aleksey Y, Kondrashov Alexey S
Abstract excerpt
Only a fraction of eukaryotic genes affect the phenotype drastically. We compared 18 parameters in 1273 human morbid genes, known to cause diseases, and in the remaining 16 580 unambiguous human genes. Morbid genes evolve more slowly, have wider phylogenetic distributions, are more similar to ess...
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