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Article

Bioinformatical assay of human gene morbidity.

Nucleic acids research - 1 Jan 2004

Kondrashov Fyodor A, Ogurtsov Aleksey Y, Kondrashov Alexey S

Abstract excerpt

Only a fraction of eukaryotic genes affect the phenotype drastically. We compared 18 parameters in 1273 human morbid genes, known to cause diseases, and in the remaining 16 580 unambiguous human genes. Morbid genes evolve more slowly, have wider phylogenetic distributions, are more similar to essential genes of Drosophila melanogaster, code for longer proteins containing more alanine and glycine and less...

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Identifiers

PMID: 15020709
DOI: 10.1093/nar/gkh330
PMCID: PMC390328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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