Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis.

doi:10.1128/JVI.80.6.3108-3111.2006

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Article

Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis.

Journal of virology - 1 Mar 2006

Lulla Valeria, Merits Andres, Sarin Peter, Kääriäinen Leevi, Keränen Sirkka, Ahola Tero

Abstract excerpt

We have sequenced the nonstructural protein coding region of Semliki Forest virus temperature-sensitive (ts) mutant strains ts1, ts6, ts9, ts10, ts11, ts13, and ts14. In each case, the individual amino acid changes uncovered were transferred to the prototype strain background and thereby identified as the underlying cause of the altered RNA synthesis phenotype. All mutations mapping to the protease domain of...

Topics

Amino Acid Substitution
Animals
Cell Line
Cricetinae
Cysteine Endopeptidases
Mutation
RNA, Viral
Recombination, Genetic
Semliki forest virus
Temperature
Viral Nonstructural Proteins

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Identifiers

PMID: 16501123
DOI: 10.1128/JVI.80.6.3108-3111.2006
PMCID: PMC1395444

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