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Article

Functional significance of the nuclear-targeting and NTP-binding motifs of Semliki Forest virus nonstructural protein nsP2.

Virology - 15 Apr 1996

Rikkonen M

Abstract excerpt

Semliki Forest virus-specific polypeptide nsP2 is a nonstructural protein involved in multiple steps during viral RNA replication. It was recently shown to possess single-stranded RNA-stimulated ATPase and GTPase activities. Replacement of the highly conserved lysine (Lys-192) within the classica...

Topics

Adenosine Triphosphate
Amino Acid Sequence
Animals
Arginine
Base Sequence
Binding Sites
Cell Line
Cell Nucleus
Cricetinae
Cytoplasm
DNA
Female
Guanosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lysine

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 8610462
DOI: 10.1006/viro.1996.0204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8610462-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Functional significance of the nuclear-targeting and NTP-binding motifs of Semliki Forest virus nonstructural protein nsP2.PMID 8610462Read ↗

Nuclear targeting of Semliki Forest virus nsP2.Semantic proximity Read ↗

Mutations in the nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest virus.Semantic proximity Read ↗

Semliki Forest Virus Nonstructural Protein 2 Is Involved in Suppression of the Type I Interferon ResponseSemantic proximity Read ↗

Nuclear and nucleolar targeting signals of semliki forest virus nonstructural protein nsP2Semantic proximity Read ↗

ATPase and GTPase activities associated with Semliki Forest virus nonstructural protein nsP2Semantic proximity Read ↗

Nuclear localization of Semliki Forest virus-specific nonstructural protein nsP2.Semantic proximity Read ↗

A Single Amino Acid Change in the Nuclear Localization Sequence of the nsP2 Protein Affects the Neurovirulence of Semliki Forest VirusSemantic proximity Read ↗

Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants.Semantic proximity Read ↗

Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.Semantic proximity Read ↗

Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription.Semantic proximity Read ↗

Deletion Analysis of a Defective Interfering Semliki Forest Virus RNA Genome Defines a Region in the nsP2 Sequence That Is Required for Efficient Packaging of the Genome into Virus ParticlesSemantic proximity Read ↗

Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivoSemantic proximity Read ↗

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