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Article

Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants.

Journal of virology - 1 Mar 2007

Balistreri Giuseppe, Caldentey Javier, Kääriäinen Leevi, Ahola Tero

Abstract excerpt

We have analyzed the biochemical consequences of mutations that affect viral RNA synthesis in Semliki Forest virus temperature-sensitive (ts) mutants. Of the six mutations mapping in the multifunctional replicase protein nsP2, three were located in the N-terminal helicase region and three were in the C-terminal protease domain. Wild-type and mutant nsP2s were expressed, purified, and assayed for nucleotide...

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Identifiers

PMID: 17202213
DOI: 10.1128/JVI.02078-06
PMCID: PMC1866018

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Source receipt: pubmed, retrieved 7 Sept 2026.

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