Genetic analysis of the yellow fever virus NS1 protein: identification of a temperature-sensitive mutation which blocks RNA accumulation.

doi:10.1128/JVI.71.1.291-298.1997

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Article

Genetic analysis of the yellow fever virus NS1 protein: identification of a temperature-sensitive mutation which blocks RNA accumulation.

Journal of virology - 1 Jan 1997

Muylaert I R, Galler R, Rice C M

Abstract excerpt

The flavivirus NS1 protein is a highly conserved nonstructural glycoprotein that is capable of eliciting protective immunity. NS1 homodimers are secreted from virus-infected mammalian cells, but the protein is also present at the plasma membrane and in the lumen of intracellular vesicles. Based o...

Topics

Alanine
Arginine
Humans
Mutagenesis, Site-Directed
Phenotype
Protein Processing, Post-Translational
Proteins
RNA, Viral
Temperature
Tumor Cells, Cultured
Viral Nonstructural Proteins
Viral Proteins
Yellow fever virus

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