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Article

Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels.

Biophysical journal - 1 Sept 2005

Hebeisen Simon, Fahlke Christoph

Abstract excerpt

Mammalian ClC-type chloride channels have large cytoplasmic carboxy-terminal domains whose function is still insufficiently understood. We investigated the role of the distal part of the carboxy-terminus of the muscle isoform ClC-1 by constructing and functionally evaluating two truncation mutants, R894X and K875X. Truncated channels exhibit normal unitary conductances and anion selectivities but altered apparent...

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Identifiers

PMID: 15980168
DOI: 10.1529/biophysj.104.056093
PMCID: PMC1366675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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