Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks.

doi:10.1529/biophysj.105.060491

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Article

Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks.

Biophysical journal - 15 May 2006

El-Samad Hana, Khammash Mustafa

Abstract excerpt

Cellular events that execute life programs are ordered and reproducible, despite the noise and randomness underlying their biochemical reactions. The identification of the processes that ensure this robust operation is essential not only to uncover the salient design principles in organisms, but also to forward-engineer reliable genetic networks for biotechnological and therapeutic purposes. The use of feedback...

Topics

Computer Simulation
Escherichia coli
Escherichia coli Proteins
Feedback
Gene Expression Regulation
Genetic Variation
Heat-Shock Proteins
Heat-Shock Response
Models, Biological
Models, Statistical
Signal Transduction
Stochastic Processes
Suppression, Genetic

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Identifiers

PMID: 16500958
DOI: 10.1529/biophysj.105.060491
PMCID: PMC1440756

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