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Article

Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks.

Biophysical journal - 15 May 2006

El-Samad Hana, Khammash Mustafa

Abstract excerpt

Cellular events that execute life programs are ordered and reproducible, despite the noise and randomness underlying their biochemical reactions. The identification of the processes that ensure this robust operation is essential not only to uncover the salient design principles in organisms, but also to forward-engineer reliable genetic networks for biotechnological and therapeutic purposes. The use of feedback...

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Identifiers

PMID: 16500958
DOI: 10.1529/biophysj.105.060491
PMCID: PMC1440756

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