Article
Analysis of sigma32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response.
Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2007
Yura Takashi, Guisbert Eric, Poritz Mark, Lu Chi Zen, Campbell Elizabeth, Gross Carol A
Abstract excerpt
Protein quality control is accomplished by inducing chaperones and proteases in response to an altered cellular folding state. In Escherichia coli, expression of chaperones and proteases is positively regulated by sigma32. Chaperone-mediated negative feedback control of sigma32 activity allows this transcription factor to sense the cellular folding state. We identified point mutations in sigma32 altered in...
Topics
- Amino Acid Sequence
- Base Sequence
- Escherichia coli
- Escherichia coli Proteins
- Feedback
- Gene Expression Regulation, Bacterial
- Heat-Shock Proteins
- Molecular Chaperones
- Mutation
- Plasmids
- Point Mutation
- Sigma Factor