Article
A Novel SRP Recognition Sequence in the Homeostatic Control Region of Heat Shock Transcription Factor σ32.
Scientific reports - 7 Apr 2016
Miyazaki Ryoji, Yura Takashi, Suzuki Takehiro, Dohmae Naoshi, Mori Hiroyuki, Akiyama Yoshinori
Abstract excerpt
Heat shock response (HSR) generally plays a major role in sustaining protein homeostasis. In Escherichia coli, the activity and amount of the dedicated transcription factor σ(32) transiently increase upon heat shock. The initial induction is followed by chaperone-mediated negative feedback to inactivate and degrade σ(32). Previous work reported that signal recognition particle (SRP)-dependent targeting of σ(32)...
Topics
- Amino Acid Sequence
- Binding Sites
- Disulfides
- Escherichia coli Proteins
- Feedback, Physiological
- HSP40 Heat-Shock Proteins
- HSP70 Heat-Shock Proteins
- HSP90 Heat-Shock Proteins
- Heat-Shock Proteins
- Homeostasis
- Immunoblotting
- Models, Molecular
- Mutation