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Article

Reeler homozygous mice exhibit enhanced susceptibility to epileptiform activity.

Epilepsia - 1 Feb 2006

Patrylo Peter R, Browning Ronald A, Cranick Scott

Abstract excerpt

PURPOSE: Seizures are observed frequently in humans with diffuse neuronal migration disorders. The reeler mutant mouse also exhibits a diffuse disruption of migration, yet no pro-epileptic phenotype has been reported for this model. Whether this disparity reflects a phenotypic difference that can be used to delineate the mechanisms associated with increasing seizure susceptibility or reflects a paucity of...

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PMID: 16499749
DOI: 10.1111/j.1528-1167.2006.00417.x

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