Article
Reeler mutant mice exhibit seizures during recovery from isoflurane-induced anesthesia.
Epilepsy research - 1 Apr 2006
Kopjas Nicholas N, Jones Ryan T, Bany Brent, Patrylo Peter R
Abstract excerpt
Reeler mice are a model of cortical malformation with enhanced seizure susceptibility. Data suggest that the propensity to anesthesia-induced seizures may be enhanced in animal models with developmental anomalies. Consequently, reeler mice were monitored behaviorally before, during and after isoflurane anesthesia. During recovery, 12% of reeler homozygotes had class I/II seizures while the remaining 88% exhibited...
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