Article
Mitochondrial dysfunction in aging and longevity: a causal or protective role?
Antioxidants & redox signaling - 20 Oct 2013
Pulliam Daniel A, Bhattacharya Arunabh, Van Remmen Holly
Abstract excerpt
SIGNIFICANCE: Among the most highly investigated theories of aging is the mitochondrial theory of aging. The basis of this theory includes a central role for altered or compromised mitochondrial function in the pathophysiologic declines associated with aging. In general, studies in various organisms, including nematodes, rodents, and humans, have largely upheld that aging is associated with mitochondrial...
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