A tryptophan hydroxylase gene marker for suicidality and alcoholism.

doi:10.1001/archpsyc.55.7.593

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Article

A tryptophan hydroxylase gene marker for suicidality and alcoholism.

Archives of general psychiatry - 1 Jul 1998

Nielsen D A, Virkkunen M, Lappalainen J, Eggert M, Brown G L, Long J C, Goldman D, Linnoila M

Abstract excerpt

BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin. Low turnover rate of this monoamine neurotransmitter is associated with impaired impulse control. We previously reported that, in Finns, TPH genotype was associated with suicidality, a pathophysiol...

Topics

Adult
Alcoholism
Disruptive, Impulse Control, and Conduct Disorders
Family
Finland
Genetic Linkage
Genetic Markers
Genetic Variation
Genotype
Humans
Introns
Male
Models, Genetic
Personality
Polymorphism, Genetic
Prisoners
Regression Analysis
Serotonin

Source

Open in PubMed

Identifiers

PMID: 9672049
DOI: 10.1001/archpsyc.55.7.593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9672049-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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