Article
A tryptophan hydroxylase gene marker for suicidality and alcoholism.
Archives of general psychiatry - 1 Jul 1998
Nielsen D A, Virkkunen M, Lappalainen J, Eggert M, Brown G L, Long J C, Goldman D, Linnoila M
Abstract excerpt
BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin. Low turnover rate of this monoamine neurotransmitter is associated with impaired impulse control. We previously reported that, in Finns, TPH genotype was associated with suicidality, a pathophysiological mechanism that may involve impaired impulse control. METHODS: Association and sib-pair linkage analyses of a...
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