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Article

Interaction between tryptophan hydroxylase I polymorphisms and childhood abuse is associated with increased risk for borderline personality disorder in adulthood.

Psychiatric genetics - 1 Feb 2012

Wilson Scott T, Stanley Barbara, Brent David A, Oquendo Maria A, Huang Yung-yu, Haghighi Fatemeh, Hodgkinson Colin A, Mann J John

Abstract excerpt

INTRODUCTION: Borderline personality disorder (BPD) is a severe disorder with high morbidity and mortality, but unknown etiology. Childhood abuse has been proposed as an etiological factor, but the mechanism by which an abuse history could influence the risk for BPD has not been determined. The aim of this study was to determine whether the tryptophan hydroxylase 1 (TPH1) gene is related to BPD in a clinical...

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Source

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Identifiers

PMID: 21989108
DOI: 10.1097/YPG.0b013e32834c0c4c
PMCID: PMC3241896

Genes

TPH1

Variants

rs4537731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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