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Article

Re-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c.

International journal of molecular medicine - 1 Mar 2016

Xiao Kang, Zhang Bao-Yun, Zhang Xiao-Mei, Wang Jing, Chen Cao, Chen Li-Na, Lv Yan, Shi Qi, Dong Xiao-Ping

Abstract excerpt

It is well known that the SMB-S15 cell line was originally established by cultures from the brains of mice affected by the Chandler scrapie strain, and this cell line may express PrPSc permanently. However, the infectivity of the S15-derived prions on experimental animals has not yet been well documented. In the present study, the cell lysates of SMB-S15 were intracerebrally inoculated into three different...

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Identifiers

PMID: 26820255
DOI: 10.3892/ijmm.2016.2465
PMCID: PMC4771105

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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