Article
Follicular dendritic cell of the knock-in mouse provides a new bioassay for human prions.
Biochemical and biophysical research communications - 7 Jun 2002
Kitamoto Tetsuyuki, Mohri Shirou, Ironside James W, Miyoshi Ichiro, Tanaka Tomoyuki, Kitamoto Noritoshi, Itohara Shigeyoshi, Kasai Noriyuki, Katsuki Motoya, Higuchi Jun, Muramoto Tamaki, Shin Ryong-Woon
Abstract excerpt
Infectious prion diseases initiate infection within lymphoid organs where prion infectivity accumulates during the early stages of peripheral infection. In a mouse-adapted prion infection, an abnormal isoform (PrP(Sc)) of prion protein (PrP) accumulates in follicular dendritic cells within lymphoid organs. Human prions, however, did not cause an accumulation of PrP(Sc) in the wild type mice. Here, we report that...
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