Article
Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and human hepatitis B virus (HBV) replication.
Journal of medicinal chemistry - 14 Oct 2010
Srivastav Naveen C, Shakya Neeraj, Mak Michelle, Agrawal Babita, Tyrrell D Lorne, Kumar Rakesh
Abstract excerpt
Despite the existence of successful vaccine and antiviral therapies, infection with hepatitis B virus (HBV) continues to be a major global cause of acute and chronic liver disease and high mortality. We synthesized and evaluated several lyxofuranosyl, 2'-fluoroxylofuranosyl, 3'-fluoroarabinofuranosyl, and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues for antiviral activities...
Topics
- Animals
- Antiviral Agents
- Cell Line, Tumor
- Drug Resistance, Viral
- Ducks
- Hepatitis B Virus, Duck
- Hepatitis B virus
- Hepatocytes
- Humans
- Lamivudine
- Mutation
- Pyrimidine Nucleosides