Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.

doi:10.1021/jm020246+

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Article

Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.

Journal of medicinal chemistry - 24 Oct 2002

Chong Youhoon, Choo Hyunah, Choi Yongseok, Mathew Judy, Schinazi Raymond F, Chu Chung K

Abstract excerpt

As 2',3'-didehydro-2',3'-dideoxy-2'-fluoronucleosides have exhibited interesting antiviral effects against HIV-1 as well as HBV, it is of interest to synthesize the isosterically substituted 4'-thionucleosides in which 4'-oxygen is replaced by a sulfur atom. To study structure-activity relationships, various pyrimidine and purine nucleosides were synthesized from the key intermediate...

Topics

Animals
Anti-HIV Agents
Antiviral Agents
Binding Sites
Cell Line
Chlorocebus aethiops
Drug Resistance, Viral
HIV Reverse Transcriptase
HIV-1
Humans
Lamivudine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Models, Molecular

Mutation

Purine Nucleosides

Pyrimidine Nucleosides

Quantum Theory

Stereoisomerism

Source

Open in PubMed

Identifiers

PMID: 12383014
DOI: 10.1021/jm020246+

Provenance

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