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Article

In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance.

Hepatology (Baltimore, Md.) - 1 Jan 2000

Xiong X, Yang H, Westland C E, Zou R, Gibbs C S

Abstract excerpt

Several mutations (V521L, P525L, L528M, T532S, and V555I) in the gene for hepatitis B virus (HBV) polymerase have been identified in HBV isolated from patients that displayed break-through viremia during famciclovir treatment. To determine whether these mutations cause phenotypic resistance to famciclovir, we compared the inhibition constants (K(i)) of penciclovir triphosphate (PCVTP, the active metabolite of...

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Identifiers

PMID: 10613749
DOI: 10.1002/hep.510310132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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