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Article

Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses.

Hepatology (Baltimore, Md.) - 1 Sept 2002

Seignères Béatrice, Pichoud Christian, Martin Perrine, Furman Philip, Trépo Christian, Zoulim Fabien

Abstract excerpt

To design combination strategies for chronic hepatitis B therapy, we evaluated in vitro the inhibitory activity of 4 nucleoside analogs, (-)FTC, L-FMAU, DXG, and DAPD, in comparison with lamivudine (3TC) and PMEA. In a cell-free assay for the expression of wild-type duck hepatitis B virus (DHBV) reverse transcriptase, DAPD-TP was found to be the most active on viral minus strand DNA synthesis, including the...

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Identifiers

PMID: 12198665
DOI: 10.1053/jhep.2002.35070

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