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Article

FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells.

The Journal of biological chemistry - 28 Apr 2006

Bunker Janis M, Kamath Kathy, Wilson Leslie, Jordan Mary Ann, Feinstein Stuart C

Abstract excerpt

The neural microtubule-associated protein Tau binds directly to microtubules and regulates their dynamic behavior. In addition to being required for normal development, maintenance, and function of the nervous system, Tau is associated with several neurodegenerative diseases, including Alzheimer disease. One group of neurodegenerative dementias known as FTDP-17 (fronto-temporal dementia with Parkinsonism linked...

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PMID: 16495230
DOI: 10.1074/jbc.M509420200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells.PMID 16495230Read ↗

Modulation of Microtubule Dynamics by Tau in Living Cells: Implications for Development and NeurodegenerationSemantic proximity Read ↗

FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.Semantic proximity Read ↗

Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different MannersSemantic proximity Read ↗

FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific FashionSemantic proximity Read ↗

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assemblySemantic proximity Read ↗

A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.Semantic proximity Read ↗

Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies.Semantic proximity Read ↗

Mutated tau binds less avidly to microtubules than wildtype tau in living cells.Semantic proximity Read ↗

FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions.Semantic proximity Read ↗

Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease.Semantic proximity Read ↗

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.Semantic proximity Read ↗

Functional effects of tau gene mutations ΔN296 and N296HSemantic proximity Read ↗

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