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Article

Modulation of Microtubule Dynamics by Tau in Living Cells: Implications for Development and Neurodegeneration

16 Mar 2004

Abstract excerpt

The neural microtubule-associated protein tau binds to and stabilizes microtubules. Because of alternative mRNA splicing, tau is expressed with either 3 or 4 C-terminal repeats. Two observations indicate that differences between these tau isoforms are functionally important. First, the pattern of tau isoform expression is tightly regulated during development. Second, mutation-induced changes in tau RNA splicing...

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Identifiers

PMID: 15020716
DOI: 10.1091/mbc.e04-01-0062

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