Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

Science (New York, N.Y.) - 4 Dec 1998

Hong M, Zhukareva V, Vogelsberg-Ragaglia V, Wszolek Z, Reed L, Miller B I, Geschwind D H, Bird T D, McKeel D, Goate A, Morris J C, Wilhelmsen K C, Schellenberg G D, Trojanowski J Q, Lee V M

Abstract excerpt

Tau proteins aggregate as cytoplasmic inclusions in a number of neurodegenerative diseases, including Alzheimer's disease and hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Over 10 exonic and intronic mutations in the tau gene have been identified in about 20 FTDP-17 families. Analyses of soluble and insoluble tau proteins from brains of FTDP-17 patients indicated that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Microtubules

Share to Mutation

Share to Phosphorylation

Share to Recombinant Proteins

Share to Syndrome

Source

Identifiers

PMID: 9836646
DOI: 10.1126/science.282.5395.1914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.PMID 9836646Read ↗

Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells.Semantic proximity Read ↗

FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific FashionSemantic proximity Read ↗

Tau gene mutations: dissecting the pathogenesis of FTDP-17.Semantic proximity Read ↗

A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.Semantic proximity Read ↗

Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).Semantic proximity Read ↗

Phenotypic heterogeneity of FTDP-17: implications for the differences of pathological phenotype among sporadic tauopathies.Semantic proximity Read ↗

Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies.Semantic proximity Read ↗

FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions.Semantic proximity Read ↗

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).Semantic proximity Read ↗

Mutations causing neurodegenerative tauopathies.Semantic proximity Read ↗

Hereditary frontotemporal dementia caused by Tau gene mutations.Semantic proximity Read ↗

Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.