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Article

FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.

The Journal of biological chemistry - 26 Dec 2008

LeBoeuf Adria C, Levy Sasha F, Gaylord Michelle, Bhattacharya Arnab, Singh Ambuj K, Jordan Mary Ann, Wilson Leslie, Feinstein Stuart C

Abstract excerpt

Mutations affecting either the structure or regulation of the microtubule-associated protein Tau cause neuronal cell death and dementia. However, the molecular mechanisms mediating these deleterious effects remain unclear. Among the most characterized activities of Tau is the ability to regulate...

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Share to Cell Survival
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Share to Microtubules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Homology, Amino Acid

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Source

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Identifiers

PMID: 18940799
DOI: 10.1074/jbc.M803519200
PMCID: PMC2606000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18940799-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.PMID 18940799Read ↗

FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells.Semantic proximity Read ↗

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Modulation of Microtubule Dynamics by Tau in Living Cells: Implications for Development and NeurodegenerationSemantic proximity Read ↗

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Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different MannersSemantic proximity Read ↗

Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R.Semantic proximity Read ↗

Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactionsSemantic proximity Read ↗

FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific FashionSemantic proximity Read ↗

Tau gene mutations: dissecting the pathogenesis of FTDP-17.Semantic proximity Read ↗

Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell deathSemantic proximity Read ↗

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